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To make their discovery, Grimm and colleagues used the Science in Microgravity Box (SIMBOX) experimental facility aboard Shenzhou-8, which was launched on October 31, 2011. Cell feeding was automatically performed in space on day five and automated cell fixation was conducted on day 10. Inflight control was achieved by using a centrifuge in space. On November 17, 2011, Shenzhou-8 landed and the experimental samples were analyzed.

Additional cells were analyzed using a random positioning machine which aims to achieve simulated microgravity conditions on the ground by rotating a sample around two axes operated in a random real direction mode. Both cell types were investigated with respect to their gene expression and secretion profiles, employing modern molecular biological techniques, such as whole genome microarrays and multi-analyte profiling.

Results suggested that the expression of genes indicating a high malignancy in cancer cells may be down-regulated under altered gravitational stimulation.

“We are just at the beginning of a new field of medicine that studies the effects of microgravity on cell and molecular pathology. Space flight affects our bodies, both for good and bad,” said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal.

“We’ve known that microgravity can cause some microorganisms to become more virulent and that prolonged microgravity has negative effects on the human body. Now, we learn that it’s not all bad news: what we learn from cells in space should help us understand and treat malignant tumors on the ground.”
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*** soft link back to pic of Ripley recovering in orbit. /adds Knights Hospitaller in Spaaace to list of front organizations.

Scientists discover that thyroid cancer cells become less aggressive in outer space